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<!-- RR Donnelley Xcelerate Taxonomy Schema, based on XBRL 2.1  http://www.rrdonnelley.com/ -->
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<!-- Round: 5 -->
<!-- Creation date: 2015-10-28T00:12:43Z -->
<!-- Copyright (c) 2005-2013 R.R. Donnelley & Sons Company All Rights Reserved. -->
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        <link:definition>112 - Disclosure - Stock Based Compensation</link:definition>
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        <link:definition>113 - Disclosure - Earnings Per Share</link:definition>
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        <link:definition>114 - Disclosure - Marketable Securities</link:definition>
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        <link:definition>115 - Disclosure - Business Combinations</link:definition>
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        <link:definition>121 - Disclosure - Earnings Per Share (Tables)</link:definition>
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        <link:definition>122 - Disclosure - Marketable Securities (Tables)</link:definition>
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        <link:definition>124 - Disclosure - Business Segments (Tables)</link:definition>
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        <link:definition>125 - Disclosure - Income Taxes - Additional Information (Detail)</link:definition>
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        <link:definition>126 - Disclosure - Stock Based Compensation - Additional Information (Detail)</link:definition>
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        <link:definition>127 - Disclosure - Stock Based Compensation - Stock Based Compensation Expense Recorded in Condensed Consolidated Statements of Income (Detail)</link:definition>
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        <link:definition>128 - Disclosure - Earnings Per Share - Additional Information (Detail)</link:definition>
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        <link:definition>130 - Disclosure - Marketable Securities - Fair Value of Available for Sale Marketable Securities (Detail)</link:definition>
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        <link:definition>131 - Disclosure - Business Combinations - Additional Information (Detail)</link:definition>
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        <link:definition>132 - Disclosure - Business Combinations - Summary of Purchase Price (Detail)</link:definition>
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        <link:definition>133 - Disclosure - Business Combinations - Summary of Preliminary Fair Value of Assets Acquired and Liabilities Assumed (Detail)</link:definition>
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        <link:definition>134 - Disclosure - Business Combinations - Components of Identifiable Intangible Assets and Estimated Useful Lives (Detail)</link:definition>
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        <link:definition>135 - Disclosure - Business Combinations - Summary of Unaudited Proforma Financial Information (Detail)</link:definition>
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        <link:definition>136 - Disclosure - Business Combinations - Changes In Carrying Amount of Goodwill (Detail)</link:definition>
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        <link:definition>137 - Disclosure - Business Segments - Business Segment Information Based on Net Revenues and Net Income from Operations (Detail)</link:definition>
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        <link:definition>138 - Disclosure - Business Segments - Business Segment Information Based on Assets (Detail)</link:definition>
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        <link:usedOn>link:presentationLink</link:usedOn>
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        <link:definition>139 - Disclosure - Debt - Additional Information (Detail)</link:definition>
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        <link:definition>140 - Disclosure - Related Party Transactions - Additional Information (Detail)</link:definition>
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  <element name="CommonStockUnissuedShares" id="hstm_CommonStockUnissuedShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DenominatorAbstract" id="hstm_DenominatorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DocumentAndEntityInformationAbstract" id="hstm_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="EscrowMember" id="hstm_EscrowMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="FairValueAdjustmentToDeferredRevenueMember" id="hstm_FairValueAdjustmentToDeferredRevenueMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="HealthCareComplianceStrategiesIncMember" id="hstm_HealthCareComplianceStrategiesIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="HealthlineSystemsMember" id="hstm_HealthlineSystemsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="HealthstreamProviderSolutionsMember" id="hstm_HealthstreamProviderSolutionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="HealthstreamWorkforceSolutionsMember" id="hstm_HealthstreamWorkforceSolutionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="IncomeFromOperationsAbstract" id="hstm_IncomeFromOperationsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="InterestCoverageRatioOne" id="hstm_InterestCoverageRatioOne" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LetterOfCreditSubfacilityMember" id="hstm_LetterOfCreditSubfacilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LeverageRatioOne" id="hstm_LeverageRatioOne" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LineOfCreditFacilityIncreasedFacilitySizeDueToAccordionFeature" id="hstm_LineOfCreditFacilityIncreasedFacilitySizeDueToAccordionFeature" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LineOfCreditFacilityPercentageOfApplicableMarginForBorrowings" id="hstm_LineOfCreditFacilityPercentageOfApplicableMarginForBorrowings" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="MinimumEligiblePeriodOfServiceToReceiveCommonStock" id="hstm_MinimumEligiblePeriodOfServiceToReceiveCommonStock" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NetTangibleAssetsIncludeDeferredRevenueBookValue" id="hstm_NetTangibleAssetsIncludeDeferredRevenueBookValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NonEscrowMember" id="hstm_NonEscrowMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NumberOfEmployeesEligibleToReceiveCommonStock" id="hstm_NumberOfEmployeesEligibleToReceiveCommonStock" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NumberOfStockIncentivePlans" id="hstm_NumberOfStockIncentivePlans" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NumeratorAbstract" id="hstm_NumeratorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="PatientExperienceSolutionsMember" id="hstm_PatientExperienceSolutionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="PerformanceBasedRestrictedShareUnitsMember" id="hstm_PerformanceBasedRestrictedShareUnitsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="PreliminaryPurchasePriceAllocationMeasurementPeriod" id="hstm_PreliminaryPurchasePriceAllocationMeasurementPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ProductDevelopmentMember" id="hstm_ProductDevelopmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateEstablished" id="hstm_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateEstablished" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateRemaining" id="hstm_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateRemaining" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="StockAwardsMember" id="hstm_StockAwardsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SuntrustBankMember" id="hstm_SuntrustBankMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SwinglineSubFacilityMember" id="hstm_SwinglineSubFacilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="WriteDownOfDeferredRevenue" id="hstm_WriteDownOfDeferredRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
</schema>
